Our Research Output

Publications

70+ peer-reviewed publications in neuroscience, cell biology, and metabolism.

View on Google Scholar ↗
* equal contribution ^ graduate student # undergraduate + corresponding author

★ Featured Publications

2025
A single-cell mass cytometry-based atlas of the developing mouse brain
Van Deusen AL^, Kumar S, Calhan OY, Goggin SM, Shi J, Williams CM, Keeler AB, Fread KI, Gadani IC, +Deppmann CD, +Zunder ER
Nature Neuroscience
DOI
2024
A brain reward circuit inhibited by next-generation weight loss drugs
Godschall EN^, Gungul TB, Sajonia IR, Buyukaksakal AK, Li OD, Ogilvie S, Keeler AB, Tian G, Koita O, Shi Y, Deutsch TC, Crook M, Zhang Y, Conley NJ, Webster AN, Calhan OY, Liu W, Akkoub A, Malik K, West KI, Michel-Le S, Karthikeyan A, van Gerven G, Beier KT, Zweifel LS, Patel MK, Campbell JN, +Deppmann CD, +Guler AD
bioRxiv (preprint)
DOI
2022
A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry
Keeler AB, Van Deusen AL, Gadani IC, Williams CM, Goggin SM, Hirt AK, Vradenburgh SA, Fread KI, Puleo EA, Jin L#, Calhan OY, +Deppmann CD, +Zunder ER
Nature Neuroscience
DOI
2020
The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
Podyma B^, Johnson DA#, Sipe L^, Remcho TP#, Battin K#, Liu Y, Yoon SO, +Deppmann CD, +Güler AD
eLife
2017
Death receptor 6 promotes Wallerian degeneration in peripheral axons
Gamage KK^, Cheng I^, Park RE#, Karim MS#, Edamura K^, Hughes C, Spano AJ, Erisir A, +Deppmann CD
Current Biology
2016
Genetically targeted magnetic control of the nervous system
Wheeler MA^, Smith CJ, Ottolini M, Barker BS^, Purohit AM#, Grippo RM^, Gaykema RP, Spano AJ, Beenhakker MP, Kucenas S, Patel MK, Deppmann CD, +Güler AD
Nature Neuroscience
2014
TNFα/TNFR1 signaling is required for the development and function of primary nociceptors
#Wheeler M, ^Heffner D, ^Kim S, ^Espy S, Spano A, Cleland C, +Deppmann CD
Neuron
2014
Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival
#Suo D, ^Park J, Harrington AW, Zweifel LS, Mihalas S, +Deppmann CD
Nature Neuroscience
2008
A model for neuronal competition during development
*Deppmann CD, *Mihalas S, *Sharma N, Lonze BE, Niebur E, Ginty DD
Science

All Publications

  • 2026
    Compartment-specific transcriptome of motor neurons reveals impaired extracellular matrix signaling and activated cell cycle kinases in FUS-ALS
    Zimyanin V, Dash BP, Großmann D, Simolka T, Glaß H, Verma R, Khatri V, Deppmann C, Zunder E, Redemann S, +Hermann A
    Neurobiology of Disease
  • 2025
    ★ A single-cell mass cytometry-based atlas of the developing mouse brain
    Van Deusen AL^, Kumar S, Calhan OY, Goggin SM, Shi J, Williams CM, Keeler AB, Fread KI, Gadani IC, +Deppmann CD, +Zunder ER
    Nature Neuroscience
    DOI PubMed
  • 2025
    Characterizing microglial signaling dynamics during inflammation using single-cell mass cytometry
    +Kumar S, Kahle AD, Keeler AB, +Zunder ER, +Deppmann CD
    Glia
    DOI PubMed
  • 2025
    Extrinsic apoptosis and necroptosis in telencephalic development: a single-cell mass cytometry study
    Shi J^, Liu W, Song A, Sanni T, Van Deusen A, +Zunder ER, +Deppmann CD
    Cell Death & Differentiation
  • 2025
    Axonal spheroids are regulated by Schwann cells after peripheral nerve injury
    Hunter-Chang S^, Kim-Aun C, Karim H, Jones M, Vegiraju T, Stepanova E, Manke B, +Kucenas S, +Deppmann CD
    Glial Health Research
    DOI PubMed
  • 2025
    BDNF receptor balance gates AgRP-to-PVH fiber density and stimulation evoked feeding across caloric states
    Calhan OY, Michel-Le SK, Godschall EN, Sriramoju SS, Nunnally M, Ogilvie S, West KI, Li ODA, Vo L, Gungul TB, Nalamalapu PR, +Guler AD, +Deppmann CD
    bioRxiv In Revision
  • 2024
    ★ A brain reward circuit inhibited by next-generation weight loss drugs
    Godschall EN^, Gungul TB, Sajonia IR, Buyukaksakal AK, Li OD, Ogilvie S, Keeler AB, Tian G, Koita O, Shi Y, Deutsch TC, Crook M, Zhang Y, Conley NJ, Webster AN, Calhan OY, Liu W, Akkoub A, Malik K, West KI, Michel-Le S, Karthikeyan A, van Gerven G, Beier KT, Zweifel LS, Patel MK, Campbell JN, +Deppmann CD, +Guler AD
    bioRxiv (preprint)
    DOI PubMed
  • 2024
    Sarm1-dependent metabolic reprogramming of Schwann cells following nerve injury
    Stepanova E^, Cho C, Lee J, Pavelec CM, Tripathi A, Vegiraju T, Hunter-Chang S, Leitinger N, +Campbell JN, +Deppmann CD
    bioRxiv (preprint) In Review
    DOI PubMed
  • 2024
    Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors
    Rivet-Noor CR, Merchak AR, Render C, Gay NM, Beiter RM, Brown RM, Keeler A, Moreau GB, Li S, Olgun DG, Steigmeyer AD, Ofer R, Phan T, Vemuri K, Chen L, Mahoney KE, Shin JB, Malaker SA, Deppmann C, Verzi MP, Gaultier A
    Brain, Behavior, and Immunity
    DOI PubMed
  • 2023
    Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
    Mason AJ^, Keeler AB, Kabir F, +Winckler B, +Deppmann C
    Scientific Reports
    DOI PubMed
  • 2023
    Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network
    Tang Q, Godschall E, Brennan CD, Zhang Q, Abraham-Fan RJ, Williams SP, Güngül TB, Onoharigho R, Buyukaksakal A, Salinas R, Sajonia IR, Olivieri JJ, Calhan OY, Deppmann CD, Campbell JN, Podyma B, +Güler AD
    Science Advances
    DOI PubMed
  • 2023
    The good, the bald, and the hairy: a mechanosensor meets its fate at the target
    +Deppmann CD, +Zunder ER
    Developmental Cell (Preview)
    DOI PubMed
  • 2023
    Sexual dimorphism in the dorsal root ganglia of neonatal mice identified by protein expression profiling with single-cell mass cytometry
    Vradenburgh SA, Van Deusen AL, Beachum AN, Moats JM, Hirt AK, Deppmann CD, +Keeler AB, +Zunder ER
    Molecular and Cellular Neuroscience
    DOI PubMed
  • 2023
    Role of the caspase-8/RIPK3 axis in Alzheimer's disease pathogenesis and amyloid-beta-induced NLRP3 inflammasome activation
    Kumar S^, Budhathoki S, Oliveira CB, Kahle AD, Calhan OY, +Lukens JR, +Deppmann CD
    JCI Insight
    DOI PubMed
  • 2022
    ★ A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry
    Keeler AB, Van Deusen AL, Gadani IC, Williams CM, Goggin SM, Hirt AK, Vradenburgh SA, Fread KI, Puleo EA, Jin L#, Calhan OY, +Deppmann CD, +Zunder ER
    Nature Neuroscience
    DOI PubMed
  • 2021
    Global and regional damages in retinal ganglion cell axon bundles monitored non-invasively by visible-light OCT fibergraphy
    Grannonico M, Miller DA, Liu M, Norat P, Deppmann CD, Netland PA, Zhang HF, Liu X
    Journal of Neuroscience
  • 2020
    Regulation of degenerative spheroids after injury
    Yong Y^, Gamage K^, Cushman C#, Spano A, +Deppmann CD
    Scientific Reports
  • 2020
    ★ The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
    Podyma B^, Johnson DA#, Sipe L^, Remcho TP#, Battin K#, Liu Y, Yoon SO, +Deppmann CD, +Güler AD
    eLife
  • 2020
    CRMP4 facilitates Wallerian degeneration and axon regeneration following sciatic nerve injury
    Girouard M-P, Simas T, Hua L, Morquette B, Khazaei MR, Unsain N, Johnstone AD, Rambaldi I, Sanz RL, Raddo M-ED, Gamage KK, Yong Y, Willis DE, Verge VMK, Barker PA, Deppmann C, +Fournier AE
    eNeuro
  • 2020
    Molecular dissection of TNFR-TNFα bidirectional signaling reveals cooperative and antagonistic interactions with p75 in axon patterning
    Kuhn KD#, Edamura K^, Bhatia N#, Cheng I^, Clark SA^, Haynes CV#, Heffner DL^, Kabir F#, Velasquez J, Spano AJ, +Deppmann CD, +Keeler AB
    Molecular and Cellular Neuroscience
  • 2020
    Dopamine signaling in the suprachiasmatic nucleus enables weight gain associated with hedonic feeding
    Grippo RM, Tang Q, Zhang Q, Chadwick SR, Gao Y, Altherr EB, Sipe L, Purohit AM#, Purohit NM#, Sunkara MD, Cios KJ, Sidikpramana M, Spano AJ, Campbell JN, Steele AD, Hirsh J, Deppmann CD, Wu M, Scott MM, +Güler AD
    Current Biology
  • 2019
    p75NTR and DR6 regulate distinct phases of axon degeneration demarcated by spheroid rupture
    *Yong Y^, *Gamage K^, Cheng I^, Barford K^, Spano A, Winckler B, +Deppmann C
    Journal of Neuroscience
  • 2018
    Transcytosis of TrkA leads to diversification of dendritic signaling endosomes
    Barford K^, Keeler A, McMahon L, McDaniel K#, Yap CC, +Deppmann CD, +Winckler B
    Scientific Reports
  • 2018
    Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system
    Cheng I^, Jin L#, Rose L#, +Deppmann CD
    Developmental Neurobiology
  • 2017
    Delineating neurotrophin-3 dependent signaling pathways underlying sympathetic axon growth along intermediate targets
    *Keeler AB, *Suo D^, Park J#, +Deppmann CD
    Molecular and Cellular Neuroscience
  • 2017
    TNFα/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone
    Smith CJ, Wheeler MA^, Marjoram L, Bagnat M, Deppmann CD, Kucenas S
    PLOS Genetics
  • 2017
    ★ Death receptor 6 promotes Wallerian degeneration in peripheral axons
    Gamage KK^, Cheng I^, Park RE#, Karim MS#, Edamura K^, Hughes C, Spano AJ, Erisir A, +Deppmann CD
    Current Biology
  • 2017
    Differential sympathetic outflow to adipose depots is required for visceral fat loss in response to calorie restriction
    Sipe LM^, Yang C#, Ephrem J#, Garren E, Hirsh J, +Deppmann CD
    Nutrition & Diabetes
  • 2016
    ★ Genetically targeted magnetic control of the nervous system
    Wheeler MA^, Smith CJ, Ottolini M, Barker BS^, Purohit AM#, Grippo RM^, Gaykema RP, Spano AJ, Beenhakker MP, Kucenas S, Patel MK, Deppmann CD, +Güler AD
    Nature Neuroscience
  • 2015
    Coronin-1 and calcium signaling governs sympathetic final target innervation
    Suo D^, Park J#, Young S^, Makita T, +Deppmann CD
    Journal of Neuroscience
  • 2014
    ★ TNFα/TNFR1 signaling is required for the development and function of primary nociceptors
    #Wheeler M, ^Heffner D, ^Kim S, ^Espy S, Spano A, Cleland C, +Deppmann CD
    Neuron
  • 2014
    ★ Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival
    #Suo D, ^Park J, Harrington AW, Zweifel LS, Mihalas S, +Deppmann CD
    Nature Neuroscience
  • 2010
    Long distance control of synapse assembly by target-derived NGF
    *Sharma N, *Deppmann CD, *Harrington AW, St. Hillaire C, Chen ZY, Lee FS, +Ginty DD
    Neuron
  • 2008
    ★ A model for neuronal competition during development
    *Deppmann CD, *Mihalas S, *Sharma N, Lonze BE, Niebur E, Ginty DD
    Science

Reviews & Book Chapters

  • 2024
    Emerging roles of neuronal extracellular vesicles at the synapse
    Mason AJ, Deppmann C, Winckler B
    Neuroscientist
  • 2022
    Molecular underpinnings of developmental axon degeneration
    Yong Y, Gamage K, Hunter-Chang S, Stepanova E, Kumar S, Calhan OY, Kucenas S, Deppmann CD
    Wiring the Nervous System (Book Chapter), River Publishers
  • 2021
    Metabolic homeostasis via BDNF and its receptors
    Podyma B, Parekh K, Güler AD, +Deppmann CD
    Trends in Endocrinology & Metabolism
  • 2021
    Axonal spheroids in neurodegeneration
    Yong Y, Hunter-Chang S, Stepanova E, +Deppmann C
    Molecular and Cellular Neuroscience
  • 2021
    Long-distance regressive signaling in neural development and disease
    +Pathak A, Clark S, Bronfman FC, Deppmann CD, Carter BD
    WIREs Developmental Biology
  • 2020
    Fight or flight turns hair white
    Clark SA, +Deppmann CD
    Nature (News & Views)
  • 2017
    The neurotrophin receptor signaling endosome: where trafficking meets signaling
    Barford K^, Deppmann C, +Winckler B
    Developmental Neurobiology
  • 2017
    The evolutionary origins of antagonistic neurotrophin signaling
    Keeler AB, +Deppmann CD
    Journal of Cell Biology