Papers

google scholar profile

2023

Deppmann, C.D. and Zunder, E.R., 2023. The good, the bald, and the hairy: A mechanosensor meets its fate at the target. Developmental Cell, 58(20), pp.2013-2014.

Tang, Q., Godschall, E., Brennan, C. D., Zhang, Q., Abraham-Fan, R. J., Williams, S. P., Güngül, T. B., Onoharigho, R., Buyukaksakal, A., Salinas, R., Sajonia, I. R., Olivieri, J. J., Calhan, O. Y., Deppmann, C. D., Campbell, J. N., Podyma, B., & Güler, A. D. (2023). Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network. Science advances, 9(34), eadh9570. https://doi.org/10.1126/sciadv.adh9570

Mason, A.J., Deppmann, C. and Winckler, B., 2023. Emerging Roles of Neuronal Extracellular Vesicles at the Synapse. The Neuroscientist, p.10738584231160521.

Mason, A.J., Keeler, A.B., Kabir, F., Winckler, B. and Deppmann, C., 2023. Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles. Scientific Reports, 13(1), p.3657.

Kumar, S., Budhathoki, S., Oliveira, C. B., Kahle, A. D., Calhan, O. Y., Lukens, J. R., & Deppmann, C. D. (2023). Role of the caspase-8/RIPK3 axis in Alzheimer's disease pathogenesis and Aβ-induced NLRP3 inflammasome activation. JCI insight, 8(3), e157433. https://doi.org/10.1172/jci.insight.157433

Vradenburgh, S. A., Van Deusen, A. L., Beachum, A. N., Moats, J. M., Hirt, A. K., Deppmann, C. D., Keeler, A. B., & Zunder, E. R. (2023). Sexual dimorphism in the dorsal root ganglia of neonatal mice identified by protein expression profiling with single-cell mass cytometry. Molecular and cellular neurosciences, 126, 103866. Advance online publication. https://doi.org/10.1016/j.mcn.2023.103866

Zimyanin, V. L., Pielka, A. M., Glaß, H., Japtok, J., Großmann, D., Martin, M., Deussen, A., Szewczyk, B., Deppmann, C., Zunder, E., Andersen, P. M., Boeckers, T. M., Sterneckert, J., Redemann, S., Storch, A., & Hermann, A. (2023). Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons. Cells, 12(10), 1352. https://doi.org/10.3390/cells12101352

2022

Keeler AB, Van Deusen AL, Gadani IC, Williams CM, Goggin SM, Hirt AK, Vradenburgh SA, Fread KI, Puleo EA, Jin L, Calhan OY, +Deppmann CD, +Zunder ER. A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry. Nat Neurosci.

Favichia, M., Gibney, T., Kowalewski, K., Pani, A., Deppmann, C. Salt, Fat, Acid, Heat: Modulators of Signal Transduction. eLS.

Van Deusen, A. L., Goggin, S. M., Williams, C. M., Keeler, A. B., Fread, K. I., Cheng, I., Deppmann, C. D., Zunder, E. R. A developmental atlas of the mouse brain by single-cell mass cytometry. bioRxiv.

McDermott, C., Gaona-Gamboa, A., Lee, S. H., Sesco, E., Deppmann, C. The Role of Posttranslational Modification in Cellular Function. eLS (pp. 1-10).

2021

Grannonico, M., Miller, D., Liu, M. N., Norat, P., Deppmann, C. D., Netland, P. A., Zhang, H. F., Liu, X. R. Global and regional damages in retinal ganglion cell axon bundles monitored non-invasively by visible-light optical coherence tomography fibergraphy. Journal of Neuroscience (pp. 10179-10193)

Yong, Y., Hunter-Chang, S., Stepanova, E., Deppmann, C. Axonal spheroids in neurodegeneration. Molecular and Cellular Neuroscience 117, 103679.

Podyma, B., Parekh, K., Güler, A.D., Deppmann, C.D. Metabolic homeostasis via BDNF and its receptors. Trends in Endocrinology & Metabolism (pp. 488-499).

Pathak, A., Clark, S., Bronfman, F. C., Deppmann, C. D., Carter, B. D. Long-distance regressive signaling in neural development and disease. Developmental Biology 10 (2), e382.

2020

Yong, Y., Gamage, K., Cushman, C., Spano, A., & Deppmann, C. D. (in press). Regulation of degenerative spheroids after injury. Scientific Reports

Yong, Y., Hughes, C., & Deppmann, C. (2020). A Microfluidic Culture Platform to Assess Axon Degeneration. In Axon Degeneration (pp. 83-96). Humana, New York, NY.

Podyma B, Johnson DA, Sipe L, Remcho TP, Battin K, Liu Y, Yoon SO, +Deppmann CD, +Güler AD. (2020) The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation. Elife. PMID: 31995032.

Girouard M-P, Simas T, Hua L, Morquette B, Khazaei MR, Unsain N, Johnstone AD, Rambaldi I, Sanz RL, Raddo M-ED, Gamage KK, Yong Y, Willis DE, Verge VMK, Barker PA, Deppmann C, +Fournier AE. (2020) Collapsin response mediator protein 4 (CRMP4) facilitates Wallerian degeneration and axon regeneration following sciatic nerve injury. eNeuro. PMID: In process

Kuhn, K.D., Edamura, K., Bhatia, N., Cheng, I., Clark, S.A., Haynes, C.V., Heffner, D.L., Kabir, F., Velasquez, J., Spano, A.J., +Deppmann, C.D., and +Keeler AB 2020. Molecular dissection of TNFR-TNFα bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning. Molecular and Cellular Neuroscience, p.103467.

Grippo RM, Tang Q, Zhang Q, Chadwick SR, Gao Y, Altherr EB, Sipe L, Purohit AM, Purohit NM, Sunkara MD, Cios KJ, Sidikpramana M, Spano AJ, Campbell JN, Steele AD, Hirsh J, Deppmann CD, Wu M, Scott MM, Güler AD. (2020) Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding. Curr Biol. PMID: 31902720.

2019

Wheeler MA, Deppmann CD, Patel MK, +Güler AD. Reply to: Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells, Assessing the utility of Magneto to control neuronal excitability in the somatosensory cortex and Revaluation of magnetic properties of Magneto. Nat Neurosci. 2019 PMID: 31570860

*Yong, Y., *Gamage, K., Cheng, I., Barford, K., Spano, A., Winckler, B. and +Deppmann, C., (2019). p75NTR and DR6 regulate distinct phases of axon degeneration demarcated by spheroid rupture. Journal of Neuroscience39(48), pp.9503-9520. PMID 31902720

2018

Ray, S., Tillo, D., Assad, N., Ufot, A., Deppmann, C., Durell, S.R., Porollo, A. and Vinson, C., 2018. Replacing C189 in the bZIP domain of Zta with S, T, V, or A changes DNA binding specificity to four types of double-stranded DNA. Biochemical and biophysical research communications501(4), pp.905-912.

Cheng, I., Jin, L., Rose, L.C. and Deppmann, C.D., 2018. Temporally restricted death and the role of p75 NTR as a survival receptor in the developing sensory nervous system. Developmental neurobiology.

Barford, K., Keeler, A., McMahon, L., McDaniel, K., Yap, C.C., Deppmann, C.D. and Winckler, B., 2018. Transcytosis of TrkA leads to diversification of dendritic signaling endosomes. Scientific reports8(1), p.4715.

2017

Sipe, L. M., C. Yang, J. Ephrem, E. Garren, J. Hirsh, and C. D. Deppmann. "Differential sympathetic outflow to adipose depots is required for visceral fat loss in response to calorie restriction." Nutrition & diabetes 7, no. 4 (2017): e260.

Smith, C.J., Wheeler, M.A., Marjoram, L., Bagnat, M., Deppmann, C.D. and Kucenas, S., 2017. TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. PLoS genetics13(4), p.e1006712.

Gamage, K.K., Cheng, I., Park, R.E., Karim, M.S., Edamura, K., Hughes, C., Spano, A.J., Erisir, A. and Deppmann, C.D. Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons. Current BiologyCurrent Biology (2017)

2016

Wheeler MA, Smith CJ, Ottolini M, Barker BS, Purohit AM, Grippo RM, Gaykema RP, Spano AJ, Beenhakker MP, Kucenas S, Patel MK, Deppmann CD, Güler AD. Genetically targeted magnetic control of the nervous system. (2016) Nature Neuroscience

See Also: This article has been covered by 20 independent international news agencies including The Guardian, The Scientist, Daily Mail, Fox News and Arstechnica (as of March 25th, 2016).  Nature Reviews will be highlighting it in the upcoming issue. Online attention and activity reported by Altmetric scores this article in the 99th percentile compared to all other articles of the same age and is the 22nd out of roughly 3000 Nature neuroscience articles.  For more context see:  https://nature.altmetric.com/details/6133441#score

2015

Suo, D., Park, J., Young, S., Makita, T., & Deppmann, C. D. (2015). Coronin-1 and Calcium Signaling Governs Sympathetic Final Target Innervation. The Journal of Neuroscience, 35(9), 3893-3902.  

2014

Wheeler, M., Heffner, D., Kim, S., Espy S., Spano, A. Cleland, C., & Deppmann, CD (2014) TNFα/TNFR1 forward and reverse signaling is required for the development and function of primary nociceptors. Neuron 82(3):587-602. Link

See Also:  Science Signaling Editor's Choice: Dual Action Pain Modulator. Link

Sokolowski, J. D., Gamage, K. K., Heffron, D. S., LeBlanc, A. C., Deppmann, C. D., & Mandell, J. W. (2014). Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury. Acta neuropathologica communications2, 16. Link

Parameswaran, Nevi, Benjamin G. Dewals, Tom C. Giles, Christopher Deppmann, Martin Blythe, Alain Vanderplasschen, Richard D. Emes, and David Haig. "The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits." Virus research (2014). Link

Suo, D., Park, J., Harrington, A. W., Zweifel, L. S., Mihalas, S., & Deppmann, C. D. (2014). Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nature neuroscience17(1), 36-45. PMID: 24270184

2012

Vaccari, A., ^Gamage, K.K., #Nachum, S., Condron, B., Deppmann C.D., Acton, S.T., (2012) Image Analysis for Automated Assessment of Axon Degeneration. Asilomar Conf. on Signals, Systems and Computers. Link

Blasier, K.R., Mitchell, D.J., Ross,M.W., Smiley,W.R., ^Suo, D., #Park, J., Pullikuth, A.K., Catling, A.D., Deppmann, C.D., Pfister, K.K. Recruitment of dynein to endosomes for retrograde survival signal transport requires specific phosphorylation of the dynein intermediate chain by a Trk/ERK pathway. J. Neuroscience (2012) 32(44):15495-510 Link

pre-2010

 *Sharma N, *Deppmann C.D., *Harrington A.W., St Hillaire C., Chen Z.Y., Lee F.S., Ginty D.D. (2010) Long-Distance Control of Synapse Assembly by Target-Derived NGF. Neuron. 2010 Aug 12;67(3):422-34. Link

See Also:

  • Video Abstract

  • Newbern, J.M., Li, X., Snider, W.D. (2010) Signaling Endosomes Trigger Synapse Assembly.  Neuron.  Aug 12;67(3):352-4. Link

  • Faculty of 1000: evaluations for Sharma et al., Neuron (2010) Link 

  • Wong, Wei. "Synapse Specification Goes Retro." Science Signalling 3.135 (2010): ec248. Link

*Deppmann, C.D., *Mihalas, S., *Sharma, N., Lonze, B.E., Niebur, E, Ginty D.D. (2008) A Model for Neuronal Competition During Development. Science, 320(5874) 369-73.  Link

See Also:

  • Davies, A.M. (2008) Neurotrophins giveth and they taketh away. Nat. Neuro. 11(6):627-8. Link

  • Li, Y., Fivaz, M. (2008) Feedback-mediated neuronal competition for survival cues regulates innervation of a target tissue. Bioessays. 30(10):929-33 Link

  • Faculty of 1000 Medicine: evaluations for Deppmann CD et al Science 2008 Apr 18 320 (5874) :369-73 http://www.f1000medicine.com/article/id/1117911/evaluation

Deppmann, C.D., Alvania, R.A., Taparowsky, E.J. (2006) Cross-species Annotation of Basic Leucine Zipper Factor Interactions: Insight Into the Evolution of Closed Interaction Networks. Mol. Biol. Evol. 23(8), 1480-92. Link

Deppmann, C.D., Acharya, A., Rishi, V., Wobbes, B., Smeekens, S., Taparowsky, E.J., Vinson, C. (2004). Dimerization Specificity of All 67 B-ZIP Motifs in Arabidopsis thaliana: A Comparison to Homo sapiens B-ZIP Motifs. Nuc. Acids Res. 32(11), 3435-45. Link

Deppmann, C.D., Thornton T.M., Utama, F.E., Taparowsky, E.J. (2003). Phosphorylation of BATF Regulates DNA binding: a Novel Mechanism for AP-1 (Activator Protein-1) Regulation. Biochem J. 374(Pt 2), 423-31.   Link

Johansen L.M., Deppmann, C.D., Erickson K.D., Coffin W.F. 3rd, Thornton T.M., Humphrey S.E., Martin, J.M. Taparowsky, E.J. (2003). BATF is a Cellular Target of the Epstein-Barr Virus Transactivator Protein, EBNA-2. J. Virol. 77, 6029-40.  Link

Williams K.L., Zullo, A.J., Kaplan, M.H., Brutkiewicz, R.R., Deppmann, C.D., Vinson C, Taparowsky, E.J. (2003). BATF Transgenic Mice Reveal a Role for AP-1 in NKT Cell Development. J. Immunol. 170, 2417-26.  Link

Deppmann, C.D., Taparowsky, E.J. (2003). Reverse-polarity PAGE for examining DNA binding domain phosphorylation. Biotechniques. 34, 56-9.

Book Chapters and Reviews:

2020

Clark, S.A., and +Deppmann, C.D., (2020). Fight or Flight Turns Hair White. (2020) Nature PMID: 31988402

Pathak, A., Clark, S., Bronfman, F.C., Deppmann, C.D. and Carter, B.D., 2020. Long‐distance regressive signaling in neural development and disease. Wiley Interdisciplinary Reviews: Developmental Biology, p.e382.

2019

Cook, SR, Hart WS, Zatorski, JM, Flick M, Deppmann CD. The Signaling Involved with Wound Healing: Recent Advances and Potential Applications (2019) Encyclopedia of Life Sciences.

2018

McGirr, B.*, Tubergen, P*, Hartz, J., Myers, P., Pittman, M., Lazzara, M., Deppmann, C. A Process Controls Approach to Cell Signaling, Encyclopedia of Life Sciences.Invited review (2018) PMCID: NA

McMullen, T.*, Brown, E*, Ausrafuggaman, N., Sahu, A., Guler, A., Deppmann, C.GPCR signal transduction: Evolution by gene duplication, Encyclopedia of Life Sciences.Invited review, (2018) PMCID: NA

2017

Barford K, Keeler A, Deppmann C, Winckler B. TrkA Bumps into Its Future Self. Dev Cell. 2017 Sep 25;42(6):557–558. PMID: 28950095

Barford K, Deppmann C, Winckler B. The neurotrophin receptor signaling endosome: Where trafficking meets signaling. Dev Neurobiol. 2017 Feb 24;77(4):405–418. PMCID: PMC5661883

Yong, Yu, Heckle, Lindsay A, Arena, Kimberly A, Goertz, Jennifer E, Kucenas, Sarah, and Deppmann, Christopher D(Aug 2017) Glia Signalling during Neurological Damage and Disease. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0027501] PMCID: NA

Guessoum, Omar, Tang, Qijun, Agorsor, Israel DK, Ke, Wenfan, Li, Renyu, Danna, Cristian H, and Deppmann, Christopher D(Aug 2017) TLR Signalling: Beyond Immunity. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0027502] PMCID: NA

Keeler AB, Deppmann CD. The evolutionary origins of antagonistic neurotrophin signaling. J Cell Biol. 2017 May 1;216(5):1223–1225. PMCID: PMC5412573

Martorella M, Barford K, Winkler B, Deppmann CD. Emergent Role of Coronin-1a in Neuronal Signaling. Vitam Horm. 2017;104:113–131. PMCID: PMC5667946

2016

Ross, EF Ali, MF, Woo, LA, Chadwick, SR Lee, E. Sangston, RM, Sood, C, Zhang, Q Zhang, X, +Deppmann, CD(2016) Reverse Signaling Encyclopedia of Life SciencesPMCID: NA

2015

Huckaby A, Dombrovski M, Maher E, Naimi W, Perez M, Skyberg R, Smolko C, Barford K, Winckler B, +Deppmann CD. (November 2015) Signaling from endosomes and exosomes. Encyclopedia of Life Sciences. PMCID: NA

2013

*^Pahl, M, *^Askinazi, O., *^Hamilton, M., ^Cheng, I., ^Kuhn, J., ^Cichewicz, K., +Deppmann, C.D. (2013) Signaling via single-pass transmembrane receptors. Encyclopedia of Life Sciences.  Link

+Deppmann, C.D., and +Janes K. (2013) Cytokine-cytokine crosstalk and cell-death decisions. Systems Biology of Apopotosis. Springer publishers. Systems Biology of Apoptosis : 163-180. Link

2012

 *^Kodis, E., *^Smindek, R., *^Kefauver, J., *Heffner, D., ^Aschenbach, K., Brennan, E., #Chan, K., ^Gamage, K.K., #Lambeth, P., Lawler, J., ^Sikora, A., #Vercroysse, N., +Deppmann C.D. First Messengers. Encyclopedia of Life Sciences. (2012) Link

2006

Deppmann, C.D., Ginty D.D. (2006) Retrograde Control of Neural Circuit Formation. Cell 127(7) 1306-7. Link

  • + Corresponding Author

  • *equal contribution

  • #UVA Undergrad Student

  • ^UVA Grad student