DEPPMANN & ZUNDER LABS · READABLE ATLAS

The sensory mountain

Somatosensory diversification · E11.5–P4

Conceptual Waddington landscape. Solid routes preserve published URD or summary relationships. Dashed links denote unsampled ancestry, alignment of overlapping analyses, or a putative state. Height, spacing and motion are illustrative. The apex represents a progenitor state, not a lineage-traced single cell.

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A mountain-shaped conceptual landscape with branching trajectories reaching labeled end states.

Keeler et al. · Nature Neuroscience · 2022 · Deppmann and Zunder labs · 21 modeled outcomes/profiles

All modeled end states and marker descriptions.
End state	Markers	Interpretation	Evidence
Immature rapidly adapting touch receptor · TrkB10	TrkB+; NFH+; Calbindin-negative; CGRP-negative	Called an immature RA-LTMR in Fig. 4d. The paper reports that these RA-LTMR clusters do not yet express the mature markers Calbindin or CGRP at P4.	Source
Rapidly adapting touch receptor · TrkB11	TrkB+; Ret+; Calbindin+; CGRP+; NFH+; Thy1+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Proprioceptor · TrkC9	TrkC+; Runx3+; Calbindin+; CGRP+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Unresolved proprioceptor / touch state · TrkC11	TrkC+; Runx3+; Ret+; CGRP+; NFH+; Thy1+	Fig. 4d calls this NF3/NF4 identity unknown. Both Ret and Runx3 are expressed; a switch of fate is a hypothesis.	Source
Slowly adapting touch receptor · TrkC10	TrkC+; Ret+; Runx3-low; TuJ1-low	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
A-delta touch receptor · TrkB9	TrkB+; Ret-low; TuJ1-low; Cux1+; p75NTR+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Calbindin-positive sensory neuron · TrkA13	Calbindin+; Islet1+; MAP2+; PGP9.5+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Peptidergic nociceptor · TrkA11	c-Kit+; TrkA+; p75NTR+; PDGFR-alpha+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Nonpeptidergic nociceptor · TrkA19	CD44+; TrkA+; Ret+; NFH+; MAP2+	Fig. 8a marks N-Cadherin, p75NTR and TrkA as increasing on the branch to TrkA19; the figure does not state what the change is measured against.	Source
Nociceptor on the nonpeptidergic branch · TrkA10	Ret+; TrkA+; MAP2+; N-Cadherin+	Fig. 4d calls TrkA10 a nociceptor; the Fig. 8a summary places it on the nonpeptidergic (NP) branch.	Source
Peptidergic nociceptor · TrkA18	c-Kit+; CGRP+; TrkA+; Ret+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Peptidergic nociceptor · TrkA12	CGRP+; NFH+; PDGFR-alpha+; Sox10+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Nonpeptidergic nociceptor · TrkA17	IB4+; Ret-high; CD44+; TrkA+; NFH+	Nonpeptidergic maturation continues after P4; an endpoint here is an analysis tip, not an adult endpoint.	Source
Putative C-fiber gentle-touch receptor · TrkA6	Islet1+; NeuN+; Ret+; TrkA+; TuJ1-low	C-LTMR identity is inferred from the intersectional protein profile and RNA comparison. TH was not in the antibody panel.	Source
Myelinating Schwann cell	CD9+; cMet+; OligO4+; Sox10-low; Vimentin-low	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Non-myelinating Schwann cell	CD9+; Nestin+; Ret+; Sox10+; Vimentin+; cMet-low; OligO4-low	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Putative phagocytic satellite glia	BFABP+; Sox10+; Islet1+; NeuN+; PGP9.5+; PDGFR-alpha+	Putative neuronal cargo uptake, not a confirmed neuronal fate. Fig. 8 gives E13-P3 for this state; Fig. 3 uses it as a P4 URD tip.	Source
Satellite glial cell · SGC10	BFABP+; Sox10+; Nestin+; TrkB+; Ret+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Cycling satellite glial cell · SGC11	BFABP+; Sox10+; Ki67+; Nestin+; TrkB+; Ret+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Satellite glial cell · SGC8	BFABP+; Sox10+; Vimentin+; TrkB+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source
Satellite glial cell · SGC9	BFABP+; Sox10+; GFAP+; Cux1+	Published analysis endpoint or summary outcome; common name is a readable gloss of the marker-defined state.	Source

Every annotated connection

Earlier common ancestor: Neural crest progenitor. Destination profiles describe a state; they do not establish an increase or decrease from its parent.

All modeled connections, including inferred ancestry and analysis alignment
Connection	From → to	Marker annotation	Evidence and scope
TrkB / TrkC sensory specification	Early sensory neuronal progenitor → TrkB/TrkC sensory progenitors	Increase: TrkB, TrkC.	Published ancestry; schematic connection. The shared neural crest ancestor predates sampling; the two URD reconstructions remain separate analyses. Relationship source · Marker source
Toward rapidly adapting touch receptors	TrkB mechanoreceptor branch → Rapidly adapting touch receptors	Destination profile: TrkB+; Ret+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward proprioceptor branch	TrkC sensory branch → Proprioceptor branch	No directional marker change transcribed for this segment.	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward immature rapidly adapting touch receptor	Rapidly adapting touch receptors → Immature rapidly adapting touch receptor · TrkB10	Destination profile: TrkB+; NFH+; Calbindin-negative; CGRP-negative	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward rapidly adapting touch receptor	Rapidly adapting touch receptors → Rapidly adapting touch receptor · TrkB11	Destination profile: TrkB+; Ret+; Calbindin+; CGRP+; NFH+; Thy1+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
TrkC sensory specification	TrkB/TrkC sensory progenitors → TrkC sensory branch	Increase: Runx3, TrkC. Decrease: TrkB.	URD. Published inferred trajectory topology; not lineage tracing. Relationship source · Marker source
Toward proprioceptor	Proprioceptor branch → Proprioceptor · TrkC9	Destination profile: TrkC+; Runx3+; Calbindin+; CGRP+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward unresolved proprioceptor / touch state	Proprioceptor branch → Unresolved proprioceptor / touch state · TrkC11	Destination profile: TrkC+; Runx3+; Ret+; CGRP+; NFH+; Thy1+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
TrkB mechanoreceptor specification	TrkB/TrkC sensory progenitors → TrkB mechanoreceptor branch	Increase: TrkB. Decrease: Runx3, TrkC.	URD. Published inferred trajectory topology; not lineage tracing. Relationship source · Marker source
Toward slowly adapting touch receptor	TrkC sensory branch → Slowly adapting touch receptor · TrkC10	Destination profile: TrkC+; Ret+; Runx3-low; TuJ1-low	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward a-delta touch receptor	TrkB mechanoreceptor branch → A-delta touch receptor · TrkB9	Destination profile: TrkB+; Ret-low; TuJ1-low; Cux1+; p75NTR+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward calbindin-positive sensory neuron	TrkA/Ret diversification → Calbindin-positive sensory neuron · TrkA13	Destination profile: Calbindin+; Islet1+; MAP2+; PGP9.5+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Peptidergic diversification	Nociceptor branch → Peptidergic branch	Increase: CGRP, c-Kit, MAP2, N-Cadherin, p75NTR.	URD. Published inferred trajectory topology; not lineage tracing. Relationship source · Marker source
Nonpeptidergic diversification	Nociceptor branch → Nonpeptidergic branch	Decrease: CGRP, c-Kit, MAP2, N-Cadherin, p75NTR.	URD. Published inferred trajectory topology; not lineage tracing. Relationship source · Marker source
Toward peptidergic sub-branch	Peptidergic branch → Peptidergic sub-branch	No directional marker change transcribed for this segment.	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward peptidergic nociceptor	Peptidergic branch → Peptidergic nociceptor · TrkA11	Destination profile: c-Kit+; TrkA+; p75NTR+; PDGFR-alpha+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward nonpeptidergic nociceptor	Nonpeptidergic branch → Nonpeptidergic nociceptor · TrkA19	Destination profile: CD44+; TrkA+; Ret+; NFH+; MAP2+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward nociceptor on the nonpeptidergic branch	Nonpeptidergic branch → Nociceptor on the nonpeptidergic branch · TrkA10	Destination profile: Ret+; TrkA+; MAP2+; N-Cadherin+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward peptidergic nociceptor	Peptidergic sub-branch → Peptidergic nociceptor · TrkA18	Destination profile: c-Kit+; CGRP+; TrkA+; Ret+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward peptidergic nociceptor	Peptidergic sub-branch → Peptidergic nociceptor · TrkA12	Destination profile: CGRP+; NFH+; PDGFR-alpha+; Sox10+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward nonpeptidergic nociceptor	Nonpeptidergic branch → Nonpeptidergic nociceptor · TrkA17	Destination profile: IB4+; Ret-high; CD44+; TrkA+; NFH+	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
TrkA / Ret sensory specification	Early sensory neuronal progenitor → TrkA/Ret sensory progenitors	Increase: TrkA.	Published ancestry; schematic connection. The shared neural crest ancestor predates sampling; the two URD reconstructions remain separate analyses. Relationship source · Marker source
Toward trka/ret diversification	TrkA/Ret sensory progenitors → TrkA/Ret diversification	No directional marker change transcribed for this segment.	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward nociceptor branch	TrkA/Ret diversification → Nociceptor branch	No directional marker change transcribed for this segment.	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Toward putative c-fiber gentle-touch receptor	TrkA/Ret sensory progenitors → Putative C-fiber gentle-touch receptor · TrkA6	Destination profile: Islet1+; NeuN+; Ret+; TrkA+; TuJ1-low	URD. Published inferred trajectory topology; not lineage tracing. Relationship source
Peripheral glial specification	Neural crest progenitor → Glial progenitors	Increase: N-Cadherin, Nestin, Sox10, Vimentin.	Published summary; unsampled connection. Fig. 8 summary supplies this early neuronal/glial divergence; it is not an observed URD parent edge. Relationship source · Marker source
Schwann myelination	Immature Schwann cells → Myelinating Schwann cell	Increase: cMet, OligO4. Decrease: Sox10, Vimentin.	Published summary refinement. Published summary relationship or maturation profile. Relationship source · Marker source
Non-myelinating Schwann maturation	Immature Schwann cells → Non-myelinating Schwann cell	Increase: Nestin, Ret, Sox10, Vimentin. Decrease: cMet, OligO4.	Published summary refinement. Published summary relationship or maturation profile. Relationship source · Marker source
Putative neuronal cargo uptake	Immature satellite glia → Putative phagocytic satellite glia	Increase: neuronal markers Islet1, NeuN and PGP9.5, plus PDGFR-alpha; putative cargo, not a neuronal fate.	Published summary refinement. Putative phagocytic state in Fig. 8. Neuronal proteins may be cargo. The dashed summary arrow does not establish differentiation into a neuron. Relationship source · Marker source
Toward satellite glial cells	Immature satellite glia → Satellite glial cells	Destination profile: BFABP+; Sox2+; Sox10+; Vimentin+	Published summary refinement. Published summary relationship or maturation profile. Relationship source
Schwann differentiation	Glial progenitors → Immature Schwann cells	Increase: CD9. Decrease: BFABP, Sox2.	Published summary refinement. Published summary relationship or maturation profile. Relationship source · Marker source
Satellite glial differentiation	Glial progenitors → Immature satellite glia	Increase: BFABP, N-Cadherin, Nestin, Sox2, Sox10, Vimentin.	Published summary refinement. Published summary relationship or maturation profile. Relationship source · Marker source
SGC10 specialization	Satellite glial cells → Satellite glial cell · SGC10	Increase: Nestin, TrkB, Ret.	Published summary refinement. Published summary relationship or maturation profile. Relationship source · Marker source
Cycling SGC11 state	Satellite glial cells → Cycling satellite glial cell · SGC11	Increase: Ki67, TrkB, Nestin, Ret.	Published summary refinement. Published summary relationship or maturation profile. Relationship source · Marker source
SGC8 specialization	Satellite glial cells → Satellite glial cell · SGC8	Increase: TrkB.	Published summary refinement. Published summary relationship or maturation profile. Relationship source · Marker source
SGC9 specialization	Satellite glial cells → Satellite glial cell · SGC9	Increase: Cux1, GFAP.	Published summary refinement. Published summary relationship or maturation profile. Relationship source · Marker source
Sensory neuronal specification	Neural crest progenitor → Early sensory neuronal progenitor	Increase: Islet1, NeuN, TuJ1. Decrease: Nestin, Sox10, Vimentin.	Published summary; unsampled connection. Summary connection added before the separately reconstructed URD roots; ancestry is earlier than their sampled common root. Relationship source

Developmental time

Partial source-evidence preview. The study collected DRGs daily from E11.5 to P4, and the stage guide uses those collection ages. Figures 4d, 4e and 8a print the same ages in whole-day shorthand (E11–E18); reported windows quote the figures as printed. All 21 outcomes have phenotype windows; five internal URD segments and the common-root age remain unassigned. Published windows are not empirical segment-by-stage distributions. Figure 8 phagocytic range and Figure 3 P4 anchor remain separate evidence.

Incoming routes use their child state’s age evidence, not a measured transition time. The geometric axis is not calibrated to chronological age.

Source age evidence for every modeled state
State	Age evidence	Scope
TrkB/TrkC sensory progenitors	Reported phenotype window: E11–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence. This is an age window for the named phenotype/family in Fig. 8, not a measured age distribution of the URD segment represented by this node.
Rapidly adapting touch receptors	Reported phenotype window: E11–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence. This is an age window for the named phenotype/family in Fig. 8, not a measured age distribution of the URD segment represented by this node.
Proprioceptor branch	Reported phenotype window: E11–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence. This is an age window for the named phenotype/family in Fig. 8, not a measured age distribution of the URD segment represented by this node.
Immature rapidly adapting touch receptor · TrkB10	Reported phenotype window: E14–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Rapidly adapting touch receptor · TrkB11	Reported phenotype window: E16–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
TrkC sensory branch	Age unassigned	Figure 8 does not label this exact URD segment with an age window. Its age cannot be recovered from tree geometry, pseudotime, or descendant ages.
Proprioceptor · TrkC9	Reported phenotype window: E15–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Unresolved proprioceptor / touch state · TrkC11	Reported phenotype window: E17–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
TrkB mechanoreceptor branch	Age unassigned	Figure 8 does not label this exact URD segment with an age window. Its age cannot be recovered from tree geometry, pseudotime, or descendant ages.
Slowly adapting touch receptor · TrkC10	Reported phenotype window: E15–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence. Use the endpoint-specific Table 4d range for this cluster. Figure 8 shows an earlier window for the broader sensory family, preserved separately in secondary_summary_window.
A-delta touch receptor · TrkB9	Reported phenotype window: E13–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence. Use the endpoint-specific Table 4d range for this cluster. Figure 8 shows an earlier window for the broader sensory family, preserved separately in secondary_summary_window.
Calbindin-positive sensory neuron · TrkA13	Reported phenotype window: E15–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Peptidergic branch	Reported phenotype window: E14–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence. This is an age window for the named phenotype/family in Fig. 8, not a measured age distribution of the URD segment represented by this node.
Nonpeptidergic branch	Reported phenotype window: E14–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence. This is an age window for the named phenotype/family in Fig. 8, not a measured age distribution of the URD segment represented by this node.
Peptidergic sub-branch	Age unassigned	Figure 8 does not label this exact URD segment with an age window. Its age cannot be recovered from tree geometry, pseudotime, or descendant ages.
Peptidergic nociceptor · TrkA11	Reported phenotype window: E15–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Nonpeptidergic nociceptor · TrkA19	Reported phenotype window: P3–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Nociceptor on the nonpeptidergic branch · TrkA10	Reported phenotype window: E14–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Peptidergic nociceptor · TrkA18	Reported phenotype window: E16–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Peptidergic nociceptor · TrkA12	Reported phenotype window: E14–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Nonpeptidergic nociceptor · TrkA17	Reported phenotype window: E17–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
TrkA/Ret sensory progenitors	Reported phenotype window: E13–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence. This is an age window for the named phenotype/family in Fig. 8, not a measured age distribution of the URD segment represented by this node.
TrkA/Ret diversification	Age unassigned	Figure 8 does not label this exact URD segment with an age window. Its age cannot be recovered from tree geometry, pseudotime, or descendant ages.
Nociceptor branch	Age unassigned	Figure 8 does not label this exact URD segment with an age window. Its age cannot be recovered from tree geometry, pseudotime, or descendant ages.
Putative C-fiber gentle-touch receptor · TrkA6	Reported phenotype window: E13–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Glial progenitors	Reported phenotype window: E11–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Myelinating Schwann cell	Reported phenotype window: P0–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Non-myelinating Schwann cell	Reported phenotype window: P0–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Putative phagocytic satellite glia	Supported samples / windows: E13.5, E14.5, E15.5, E16.5, E17.5, E18.5, P0, P1, P2, P3, P4. Other stages unknown.	Two distinct source statements are retained: Fig. 8a gives a phenotype summary window E13–P3; Fig. 3b selects phagocytic glial precursors as a P4 URD tip. P4 is highlighted as a sampled anchor. The continuous reported range remains E13–P3; earlier stages are unassigned. Neuronal proteins are putative cargo, not a neuronal fate.
Satellite glial cells	Reported phenotype window: E11–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Immature Schwann cells	Reported phenotype window: E15–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Immature satellite glia	Reported phenotype window: E11–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Satellite glial cell · SGC10	Reported phenotype window: E16–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Cycling satellite glial cell · SGC11	Reported phenotype window: E16–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Satellite glial cell · SGC8	Reported phenotype window: E15–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Satellite glial cell · SGC9	Reported phenotype window: E16–P4	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.
Neural crest progenitor	Earlier ancestry context; outside sampling	Common neural crest progenitor precedes the atlas sampling. E9 labels the schematic axis, not a measured common-root gate or precise start/end for this model node.
Early sensory neuronal progenitor	Reported phenotype window: E11–E14	Published phenotype age window; this does not measure the age distribution of the full URD segment or establish onset/exclusive presence.

E11.5 · Findings

No stage-specific finding is mapped yet.

E12.5 · Findings

No stage-specific finding is mapped yet.

E13.5 · Findings

A glial state with neuronal proteins

The E13–P3 summary window includes putative phagocytic satellite glia carrying neuronal-marker signals. This is a phenotype window, not a proven onset of engulfment.

Figure 8a, Phago SGCs; mass cytometry in Figure 3q, tissue staining in Figure 3r

E14.5 · Findings

Peptidergic and nonpeptidergic profiles

The E14–P4 summary distinguishes opposite CGRP, c-Kit, MAP2, N-Cadherin and p75NTR trends in the two nociceptor groups. This dates the reported phenotype window, not a directly observed bifurcation.

Figure 8a, NP and Pep branches

A glial state with neuronal proteins

The E13–P3 summary window includes putative phagocytic satellite glia carrying neuronal-marker signals. This is a phenotype window, not a proven onset of engulfment.

Figure 8a, Phago SGCs; mass cytometry in Figure 3q, tissue staining in Figure 3r

E15.5 · Findings

A Calbindin-positive state

The atlas distinguishes Calbindin-positive sensory neurons from the named peptidergic and nonpeptidergic groups. Its Table 4d window is E15–P4; this does not establish the first appearance of individual cells.

Figure 4a and 4d, TrkA/Ret cluster 13; Figure 8a

A glial state with neuronal proteins

The E13–P3 summary window includes putative phagocytic satellite glia carrying neuronal-marker signals. This is a phenotype window, not a proven onset of engulfment.

Figure 8a, Phago SGCs; mass cytometry in Figure 3q, tissue staining in Figure 3r

E16.5 · Findings

Satellite glia diversify

Four late satellite profiles separate TrkB, GFAP/Cux1, Nestin/Ret and cycling Ki67 signatures. Their overlapping reported windows include E16–P4; the card does not assign branch birth times.

Figure 8a; supporting SGC subclusters in Figure 3d–g

A Calbindin-positive state

Figure 4a and 4d, TrkA/Ret cluster 13; Figure 8a

E17.5 · Findings

A mixed sensory identity

TrkC11 retains an unresolved proprioceptor/touch identity. Its mixed protein profile does not demonstrate a switch of fate. Table 4d reports E17–P4 for this cluster.

Figure 4d, TrkC cluster 11: Unknown NF3/NF4; Figure 8a

Satellite glia diversify

Four late satellite profiles separate TrkB, GFAP/Cux1, Nestin/Ret and cycling Ki67 signatures. Their overlapping reported windows include E16–P4; the card does not assign branch birth times.

Figure 8a; supporting SGC subclusters in Figure 3d–g

E18.5 · Findings

A mixed sensory identity

TrkC11 retains an unresolved proprioceptor/touch identity. Its mixed protein profile does not demonstrate a switch of fate. Table 4d reports E17–P4 for this cluster.

Figure 4d, TrkC cluster 11: Unknown NF3/NF4; Figure 8a

Satellite glia diversify

Four late satellite profiles separate TrkB, GFAP/Cux1, Nestin/Ret and cycling Ki67 signatures. Their overlapping reported windows include E16–P4; the card does not assign branch birth times.

Figure 8a; supporting SGC subclusters in Figure 3d–g

P0 · Findings

Two Schwann outcomes

The summary distinguishes myelinating and non-myelinating protein profiles from birth through P4. This is the Figure 8 phenotype window, not proof that myelination first begins at P0.

Figure 8a; supporting protein profiles in Figure 3h–k

Satellite glia diversify

Four late satellite profiles separate TrkB, GFAP/Cux1, Nestin/Ret and cycling Ki67 signatures. Their overlapping reported windows include E16–P4; the card does not assign branch birth times.

Figure 8a; supporting SGC subclusters in Figure 3d–g

P1 · Findings

Two Schwann outcomes

The summary distinguishes myelinating and non-myelinating protein profiles from birth through P4. This is the Figure 8 phenotype window, not proof that myelination first begins at P0.

Figure 8a; supporting protein profiles in Figure 3h–k

A mixed sensory identity

TrkC11 retains an unresolved proprioceptor/touch identity. Its mixed protein profile does not demonstrate a switch of fate. Table 4d reports E17–P4 for this cluster.

Figure 4d, TrkC cluster 11: Unknown NF3/NF4; Figure 8a

P2 · Findings

Two Schwann outcomes

The summary distinguishes myelinating and non-myelinating protein profiles from birth through P4. This is the Figure 8 phenotype window, not proof that myelination first begins at P0.

Figure 8a; supporting protein profiles in Figure 3h–k

A mixed sensory identity

TrkC11 retains an unresolved proprioceptor/touch identity. Its mixed protein profile does not demonstrate a switch of fate. Table 4d reports E17–P4 for this cluster.

Figure 4d, TrkC cluster 11: Unknown NF3/NF4; Figure 8a

P3 · Findings

Late nociceptor diversification

The TrkA19 nonpeptidergic state appears in the P3–P4 annotation window, later than the other modeled nociceptor outcomes. The reported range does not establish a lineage birth date.

Figure 4d, TrkA/Ret cluster 19; Figure 8a

A glial state with neuronal proteins

The E13–P3 summary window includes putative phagocytic satellite glia carrying neuronal-marker signals. This is a phenotype window, not a proven onset of engulfment.

Figure 8a, Phago SGCs; mass cytometry in Figure 3q, tissue staining in Figure 3r

P4 · Findings

Late nociceptor diversification

The TrkA19 nonpeptidergic state appears in the P3–P4 annotation window, later than the other modeled nociceptor outcomes. The reported range does not establish a lineage birth date.

Figure 4d, TrkA/Ret cluster 19; Figure 8a

An endpoint can remain immature

At P4, TrkB10 is still classified as an immature rapidly adapting touch receptor. A trajectory tip can precede full maturation.

Figure 4d, TrkB cluster 10

A mixed sensory identity

TrkC11 retains an unresolved proprioceptor/touch identity. Its mixed protein profile does not demonstrate a switch of fate. Table 4d reports E17–P4 for this cluster.

Figure 4d, TrkC cluster 11: Unknown NF3/NF4; Figure 8a